Fig. 12. Over-expression of PTEN expression with PTEN-GV141 inhibits the migration-associated protein of FLSs. (A) The protein levels of PTEN, MMP-9 and TIMP-1 were analyzed by western blot in AIA FLSs transfected with PTEN-GV141. (B) The mRNA levels of PTEN, MMP-9, and TIMP-1 were analyzed by q-PCR in FLSs transfected with PTEN-GV141. All values are expressed as mean ± SD. ^## P<0.01 vs. normal group; ^*P<0.05, ^**P<0.01 vs. AIA group.